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2020-06-14 05:36:20
The human body contains approximately 245 different bones on which the soft tissues rest. Most of the muscles attach to the bones. Joints serve for movable articulation of bones. Very often diseases of bones and joints appear as a result of injuries or internal diseases of the body. What are these diseases and how to properly treat them?
The bacteriolytic effect is noted. The medication is active in aerobic / anaerobic gram-positive, aerobic gram-negative microorganisms. It is very effective against strains that are able to produce beta-lactamase..
Under the influence of clavulanic acid, the resistance of amoxicillin to the influence of a substance such as beta-lactamase is enhanced. At the same time, an expansion of the effect of this substance.
The drug is active against:
Bronchopneumonia can affect people of any age, adults, babies, but it tends to have a greater effect on certain groups of people at risk, such as:
Risk factors that may contribute to infection:
Both active ingredients of Augmentin (cheap augmentin online), amoxicillin and clavulanic acid, are rapidly and completely absorbed from the gastrointestinal tract (GIT) after oral administration. http://cold.emedtv.com/augmentin-xr/augmentin-xr-and-pregnancy.html The absorption of the active ingredients of the drug Augmentin ® is optimal when taking the drug at the beginning of a meal.
The pharmacokinetic parameters of amoxicillin and clavulanic acid, obtained in different studies, when healthy fasting volunteers took:
1 tablet of Augmentin ® 250 mg + 125 mg (375 mg);
2 tablets of the drug Augmentin ®, 250 mg + 125 mg (375 mg);
1 tablet of the drug Augmentin ®, 500 mg + 125 mg (625 mg);
500 mg of amoxicillin;
125 mg clavulanic acid.
Basic pharmacokinetic parameters
Amoxicillin
Augmentin ®, 250 mg + 125 mg
Augmentin ®, 250 mg + 125 mg, 2 tablets
Augmentin ®, 500 mg + 125 mg
Amoxicillin 500 mg
Clavulanic acid
Augmentin ®, 250 mg + 125 mg
Augmentin ®, 250 mg + 125 mg, 2 tablets
Clavulanic acid, 125 mg
Augmentin ®, 500 mg + 125 mg
Cmax - maximum plasma concentration.
Tmax - time to reach maximum plasma concentration.
AUC - area under the concentration – time curve.
T1 / 2 - half-life.
When using the drug Augmentin ®, plasma concentrations of amoxicillin are similar to those with oral administration of equivalent doses of amoxicillin.
Distribution
As with the intravenous combination of amoxicillin with clavulanic acid, therapeutic concentrations of amoxicillin and clavulanic acid are found in various tissues and interstitial fluid (in the gallbladder, abdominal tissues, skin, adipose and muscle tissues, synovial and peritoneal fluids, bile, and purulent discharge)..
Amoxicillin and clavulanic acid have a weak degree of binding to plasma proteins. Studies have shown that about 25% of the total amount of clavulanic acid and 18% of amoxicillin in blood plasma binds to plasma proteins.
In animal studies, no cumulation of the components of the Augmentin ® preparation in any organ was found.
Amoxicillin, like most penicillins, passes into breast milk. Traces of clavulanic acid may also be found in breast milk. With the exception of the possibility of sensitization, diarrhea, or candidiasis of the oral mucosa, no other negative effects of amoxicillin and clavulanic acid on the health of breast-fed babies are known.
Animal reproductive studies have shown that amoxicillin and clavulanic acid cross the placental barrier. However, no adverse effects on the fetus were detected..
10-25% of the initial dose of amoxicillin is excreted by the kidneys in the form of an inactive metabolite (penicilloic acid). Clavulanic acid is extensively metabolized to 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1 H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and excreted by the kidneys through the digestive tract, as well as with expired air in the form of carbon dioxide.
Like other penicillins, amoxicillin is excreted mainly by the kidneys, while clavulanic acid is excreted by both the renal and extrarenal mechanisms. About 60-70% of amoxicillin and about 40-65% of clavulanic acid are excreted by the kidneys unchanged in the first 6 hours after the appointment of 1 tablet of the drug Augmentin ®, film-coated tablets, 250 mg + 125 mg or 500 mg + 125 mg. The simultaneous administration of probenecid slows the excretion of amoxicillin, but not clavulanic acid (see section "Interaction with other drugs").
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